• Thumbnail for Cyclin D1
    Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the...
    49 KB (5,694 words) - 22:42, 27 March 2024
  • Thumbnail for Cyclin D
    proteins have been identified. The three homologues, called cyclin D1, cyclin D2, and cyclin D3 are expressed in most proliferating cells and the relative...
    39 KB (4,605 words) - 22:37, 27 March 2024
  • Thumbnail for Cyclin
    Cyclins are proteins that control the progression of a cell through the cell cycle by activating cyclin-dependent kinases (CDK). Cyclins were originally...
    19 KB (1,760 words) - 15:37, 20 September 2024
  • Thumbnail for Cyclin-dependent kinase complex
    of a protein kinase, cyclin-dependent kinase (CDK), with a regulatory subunit, cyclin. Once cyclin-dependent kinases bind to cyclin, the formed complex...
    18 KB (2,258 words) - 22:16, 16 December 2023
  • Thumbnail for Mantle cell lymphoma
    surrounds normal germinal center follicles. MCL cells generally over-express cyclin D1 due to the t(11:14) translocation, a chromosomal translocation in the...
    41 KB (4,549 words) - 08:59, 25 January 2024
  • Thumbnail for Epithelioid sarcoma
    cancer. Cyclin D1 is a protein requisite for cell cycle progression and has been shown to be up-regulated in epithelioid sarcoma. Cyclin D1 is a regulator...
    52 KB (5,913 words) - 20:45, 30 May 2024
  • Thumbnail for Cyclin-dependent kinase 4
    Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the...
    21 KB (2,358 words) - 04:07, 16 September 2024
  • The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine...
    25 KB (2,805 words) - 03:43, 6 May 2024
  • downregulate cyclin D1, a cyclin-dependent kinase, if they are not stimulated by the presence of mitogens. In the presence of mitogens, sufficient cyclin D1 can...
    13 KB (1,750 words) - 10:12, 12 August 2024
  • Thumbnail for B-cell lymphoma
    lymphoma, the other protein in the fusion is c-myc (on chromosome 8) and cyclin D1 (on chromosome 11), respectively, which gives the fusion protein pro-proliferative...
    11 KB (977 words) - 12:47, 19 February 2023