receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which...

ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene. Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally...

the brand name Xospata, is an anti-cancer drug. It acts as an inhibitor of FLT3, hence it is a tyrosine kinase inhibitor. It was developed by Astellas Pharma...

for oncogenic FLT3, in combination with chemotherapy. The drug is approved for use with a companion diagnostic, the LeukoStrat CDx FLT3 Mutation Assay...

to FLT3-ITD, FLT3-D835H and FLT3-D835Y with Kd of 0.74 nM, 0.4 nM, and 0.18 nM, respectively. Crenolanib inhibits the phosphorylation of the FLT3-ITD...

tyrosine kinase inhibitor. Its molecular target is FLT3, also known as CD135 which is a proto-oncogene. FLT3 mutations are among the most common mutations...

future. FLT3 internal tandem duplications (ITDs) have been shown to confer a poorer prognosis in AML with normal cytogenetics. Several FLT3 inhibitors...

FLT3 interacting zinc finger 1 is a protein that in humans is encoded by the FIZ1 gene. This gene encodes zinc finger protein, which interacts with a receptor...

and CSF1R also belong to this receptor class. FLT3 protein binds and is activated by the FLT3 ligand; FLT3 protein activation involves its forming dimers...

inhibitor (TKI) of c-Met (HGFR) and VEGFR2, and also inhibits AXL, RET, and FLT3. It was discovered and developed by Exelixis Inc. In November 2012, cabozantinib...