Granzyme B (GrB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells....
16 KB (1,920 words) - 16:20, 9 June 2024
Granzymes are serine proteases released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells. They induce programmed cell death...
14 KB (1,786 words) - 13:08, 2 June 2024
unique and parallel to that of Granzyme B, although some substrates such as PARP-1 and lamin B are shared with Granzyme B. Substrates of GzmA include Pro-IL-1β...
13 KB (1,629 words) - 03:26, 25 December 2023
influence of blood pressure. Other reports have suggested the serine protease granzyme B may contribute to aortic aneurysm rupture through the cleavage of decorin...
78 KB (8,772 words) - 02:46, 14 August 2024
Regulatory T cells can produce Granzyme B, which in turn can induce apoptosis of effector cells. Regulatory T cells from Granzyme B deficient mice are reported...
79 KB (9,493 words) - 15:51, 21 June 2024
protease Granzyme B, cytotoxic T-cells and NK cells are able to induce apoptosis in target cell. SCs produce PI-9 that irreversibly bonds Granzyme B and inhibits...
26 KB (3,062 words) - 14:58, 7 April 2024
plasma membrane pore model was challenged when research revealed that granzyme B could undergo endocytosis independently of perforin. Moreover, experiments...
16 KB (1,990 words) - 11:22, 29 June 2024
angiogenesis, blood coagulation, abolishing detachment activity by GrB (Granzyme B), and tumour metastasis. HS has also been shown to serve as cellular...
36 KB (4,151 words) - 06:37, 27 May 2024
cell death through release of a number of molecules, including perforin, granzyme B, and granulysin. Other agents, including tumor necrosis factor alpha and...
25 KB (2,603 words) - 07:54, 19 July 2024
Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer...
2 KB (327 words) - 20:07, 26 January 2024