Hereditary spastic paraplegia (HSP) is a group of inherited diseases whose main feature is a progressive gait disorder. The disease presents with progressive...

depending on whether additional clinical features are present besides spastic paraplegia, such as optic atrophy, ataxia, peripheral neuropathy, extrapyramidal...

Spastic paraplegia 31 is a rare type of hereditary spastic paraplegia which is characterized by sensation anomalies of the lower extremities. People with...

Spastic paraplegia 6 is a rare type of hereditary spastic paraplegia characterized by muscle tone and bladder anomalies associated with pes cavus and specific...

Spastic paraplegia 15 (SPG15) is a form of hereditary spastic paraplegia that commonly becomes apparent during childhood or adolescence (e.g. between ages...

types of symptoms. Damage to the upper motor neuron typically causes spasticity including stiffness and increased tendon reflexes, and/or clonus, while...

basal ganglia on magnetic resonance imaging. Hereditary spastic paraplegias are a diverse class of hereditary degenerative spinal cord disorders characterized...

Warburg Micro syndrome (WARBM), a Complex Hereditary Spastic Paraplegia or RAB18 Deficiency, is a rare autosomal recessive genetic disorder characterized...

is not routinely recommended because there are only rare instances of hereditary DLB. Many neurodegenerative conditions share cognitive and motor symptoms...

dominant spastic paraplegia 10. KIF5A has been shown to interact with KLC1. Mutations in KIF5A have been reported to cause hereditary spastic paraplegia type...