Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral targeted therapy medication used...
71 KB (6,702 words) - 05:32, 9 August 2024
Chronic myelogenous leukemia (section Imatinib)
action as a tyrosine kinase, targeted therapies (the first of which was imatinib) that specifically inhibit the activity of the BCR-ABL protein have been...
34 KB (3,877 words) - 01:25, 22 July 2024
kinase. Before the 2001 U.S. Food and Drug Administration (FDA) approval of imatinib, no drugs were available to alter the natural progression of CML. Only...
56 KB (6,475 words) - 07:21, 26 August 2024
exon 17 are responsible for resistance to targeted therapy drugs like imatinib mesylate, a tyrosine kinase inhibitor. KIT-p.D419del (exon 8) — A subset...
43 KB (4,502 words) - 18:59, 16 July 2024
patent imatinib mesylate in beta crystalline form (rather than imatinib or imatinib mesylate); thus they sought to prevent extant literature on imatinib or...
43 KB (5,296 words) - 17:09, 8 June 2024
the years. However, French scientists treating leukemia patients with imatinib, a drug used in treating cancer, noted an unexpected side effect: some...
16 KB (1,854 words) - 23:35, 10 August 2024
Tyrosine kinase (section GIST and Imatinib)
step for the development of cancer. Therefore, kinase inhibitors, such as imatinib and osimertinib, are often effective cancer treatments. Most tyrosine kinases...
43 KB (5,251 words) - 10:44, 24 June 2024
CML CP) or Ph+ CML CP resistant or intolerant to prior therapy including imatinib. newly diagnosed Ph+ acute lymphoblastic leukaemia (ALL) in combination...
22 KB (1,994 words) - 04:41, 3 January 2024
tissue. One of the most successful molecular targeted therapeutics is imatinib, marketed as Gleevec, which is a kinase inhibitor with exceptional affinity...
20 KB (2,234 words) - 01:21, 22 July 2024
anion, the spelling used is sometimes mesilate (as in imatinib mesilate, the mesylate salt of imatinib). Mesylate esters are a group of organic compounds...
4 KB (373 words) - 22:32, 16 February 2024