Lepirudin is an anticoagulant that functions as a direct thrombin inhibitor. Brand name: Refludan, Generic: Lepirudin rDNA for injection. Lepirudin is...

may be used in patients with renal dysfunction. (This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared). Argatroban...

with genetic engineering. It is now available in a recombinant form as lepirudin (Refludan) and desirudin (Revasc, Iprivask). Development of other DTIs...

needed] According to a systematic review, people with HIT treated with lepirudin showed a relative risk reduction of clinical outcome (death, amputation...

inhibitor. Current members of this class include the bivalent drugs hirudin, lepirudin, and bivalirudin and the monovalent drugs argatroban and dabigatran. An...

including: recombinant hirudin derived from Hansenula (Thrombexx, Extrauma) lepirudin (Refludan) – differs by one amino acid substitution and removal of sulfate...

September 2006. Fabrizio MC (2001). "Use of Ecarin Clotting Time (ECT) with Lepirudin Therapy in Heparin-Induced Thrombocytopenia and Cardiopulmonary Bypass"...

thrombosis. Treatment may include a direct thrombin inhibitor, such as lepirudin or argatroban. Other "blood thinners" sometimes used in this setting include...

under development; some members are already in clinical use (such as lepirudin, argatroban, bivalirudin and dabigatran). Also in clinical use are other...

Karl-Georg; Van de Loo, Andreas; Bohler, Joachim (1999). "Recombinant hirudin (lepirudin) as anticoagulant in intensive care patients treated with continuous hemodialysis"...