Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene. SOX-9 recognizes the sequence CCTTGAG along with other members of the...

that causes upregulation of other transcription factors, most importantly SOX9. Its expression causes the development of primary sex cords, which later...

nucleotide variants been identified involving the SOX9 gene that cause some form of CMD. The SOX9 gene codes for a protein transcription factor which...

tissue while the poles both contain ovarian tissue. Experiments involving the SOX9 gene, which is initiated by the SRY region of the Y chromosome, have shown...

the sex-determining region of the Y-chromosome, the SRY. The SRY activates Sox9, which forms feedforward loops with FGF9 and PGD2 in the gonads, allowing...

violation. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the...

mutation was described by Bohlen et al. (2017) in a Kozak-like region in the SOX9 gene that created a new translation initiation codon in an out-of-frame open...

example, it has been proposed that mutations in the SOX9 gene may contribute to this syndrome, as SOX9 plays a role in testes differentiation during development...

cases, the SOX9 gene, involved in the development of testes, can induce their development without the aid of SRY. In the absence of SRY and SOX9, no testes...

(possibly at the SOX9 gene or the KCNJ2 gene) have all been implicated in PRS. Some evidence suggests that genetic dysregulation of the SOX9 gene (which encodes...