CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4 (protein arginine N-methyltransferase 4), is an enzyme (EC 2.1.1.125)...
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of malate dehydrogenase 1 (MDH1). Protein arginine N-methyltransferase CARM1 methylates and inhibits MDH1 by disrupting its dimerization, which represses...
6 KB (801 words) - 19:00, 1 September 2024
negatively regulates MDH1. Protein arginine methyltransferase 4 (PRMT4/CARM1) methylates and inhibits MDH1 by disrupting its dimerization. Arginine methylation...
6 KB (770 words) - 01:49, 11 December 2023
mediated by CARM1 and is recruited to promoter upon gene activation along with acetyltransferases and activates transcription. When CARM1 is recruited...
17 KB (1,286 words) - 16:36, 29 April 2024
Protein arginine N-methyltransferase-4 (PRMT4/CARM1) methylation of arginine residues within proteins plays a critical key role in transcriptional regulation...
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Roeder RG (June 2004). "Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53". Cell. 117 (6): 735–48. doi:10.1016/j...
124 KB (13,220 words) - 11:01, 30 August 2024
arginine residues on histone tails. The first type of PRMTs (PRMT1, PRMT3, CARM1⧸PRMT4, and Rmt1⧸Hmt1) produce monomethylarginine and asymmetric dimethylarginine...
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Q96LW7 2159 CARF HGNC:14435 Q8N187 2160 CARHSP1 HGNC:17150 Q9Y2V2 2161 CARM1 HGNC:23393 Q86X55 2162 CARMIL1 HGNC:21581 Q5VZK9 2163 CARMIL2 HGNC:27089...
277 KB (17 words) - 19:37, 1 October 2024
expression. Examples of coactivators that display HAT activity include CARM1, CBP and EP300. Many coactivators also function as corepressors under certain...
18 KB (1,698 words) - 10:42, 3 December 2023
glucose shortage, the energy sensor AMPK activates arginine methyltransferase CARM1 and mediates histone H3 hypermethylation (H3R17me2), leading to enhanced...
12 KB (1,489 words) - 23:40, 26 August 2024