C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it...
67 KB (7,845 words) - 11:20, 5 August 2024
CCR5 receptor antagonists are a class of small molecules that antagonize the CCR5 receptor. The C-C motif chemokine receptor CCR5 is involved in the process...
50 KB (5,518 words) - 03:23, 5 December 2023
Innate resistance to HIV (section CCR5 deletion)
that causes AIDS. The main mechanism is a mutation of the gene encoding CCR5, which acts as a co-receptor for HIV. It is estimated that the proportion...
14 KB (1,725 words) - 13:41, 7 August 2024
making the body more susceptible to other infections. CCR5-Δ32 is an allelic variant of CCR5 gene with a 32 base pair deletion that results in a truncated...
13 KB (1,568 words) - 13:36, 2 February 2024
gp120 which blocks binding and infection of viral strains which use the CCR5 receptor to infect cells. Peptide T has several positive effects related...
14 KB (1,377 words) - 05:34, 21 January 2024
technology for modifying DNA. The embryos' genomes were edited to remove the CCR5 gene in an attempt to confer genetic resistance to HIV. The clinical project...
103 KB (11,578 words) - 05:13, 12 August 2024
use the β-chemokine receptor, CCR5, for entry and are thus able to replicate in both macrophages and CD4+ T cells. This CCR5 co-receptor is used by almost...
125 KB (14,365 words) - 18:21, 14 August 2024
medication used to treat HIV infection. It is taken by mouth. It is in the CCR5 receptor antagonist class. It was approved for medical use in the United...
12 KB (954 words) - 13:32, 23 April 2024
Vicriviroc (section CCR5-Δ32)
Vicriviroc, previously named SCH 417690 and SCH-D, is a pyrimidine CCR5 entry inhibitor of HIV-1. It was developed by the pharmaceutical company Schering-Plough...
17 KB (2,046 words) - 02:22, 27 December 2023
Germany, including Gero Hütter). From 60 matching donors, they selected a [CCR5]-Δ32 homozygous donor, an individual with two genetic copies of a rare variant...
14 KB (1,187 words) - 18:27, 23 July 2024