Chemical ligation is the chemoselective condensation of unprotected peptide segments enabled by the formation of a non-native bond at the ligation site...

Native Chemical Ligation (NCL) is an important extension of the chemical ligation concept for constructing a larger polypeptide chain by the covalent condensation...

molecules Chemical ligation, the chemoselective condensation of unprotected peptides In medicine, the making of a ligature (tie) Tubal ligation, a method...

fragments made by synthesis, chemical biologists can use the process of native chemical ligation. Native chemical ligation involves the coupling of a C-terminal...

traditional resin-based solid phase techniques would be better. Native chemical ligation (NCL) is a convergent synthetic strategy based on the linear coupling...

Protein chemical synthesis by native peptide ligation of unprotected peptide segments is an interesting complement and potential alternative to the use...

Amide-Forming Ligation is a chemical reaction that is used to join two unprotected fragments in peptide synthesis. It is an alternative to the Native Chemical Ligation...

nucleophiles, giving amides: This reaction is exploited in native chemical ligation, a protocol for peptide synthesis. In a related reaction, thioesters...

segment (called an intein) is removed from a precursor protein with a ligation of C-terminal and N-terminal external proteins (called exteins) on both...

real time in living systems without cellular toxicity. A number of chemical ligation strategies have been developed that fulfill the requirements of bioorthogonality...