DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, is an enzyme that plays a crucial role in repairing DNA double-strand breaks and...
33 KB (3,807 words) - 02:32, 6 August 2024
one DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA ends to enable the binding of Artemis protein to one end of each DNA-PKcs. One...
43 KB (5,681 words) - 00:50, 14 June 2024
Winters TA, Georgakilas AG (2010). "DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells". Free...
42 KB (3,756 words) - 04:23, 25 March 2024
Topoisomerase (redirect from Dna topoisomerases)
components of the non-homologous end joining DNA repair pathway, including DNA-PKcs, Ku70/Ku80 and DNA ligase IV assembled with topo IIβ and PARP-1....
57 KB (6,173 words) - 00:11, 11 December 2023
Non-homologous end joining (category DNA repair)
forms a complex with DNA-PKcs, which is present in mammals but absent in yeast. Ku is a basket-shaped molecule that slides onto the DNA end and translocates...
28 KB (3,683 words) - 04:20, 22 August 2024
Winters TA, Georgakilas AG (2010). "DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells". Free...
96 KB (10,994 words) - 05:19, 16 August 2024
2004). "Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice". EMBO Reports. 5 (5): 503–09. doi:10.1038/sj.embor.7400127...
129 KB (15,900 words) - 06:12, 13 August 2024
Double-strand break repair model (category DNA repair)
recruitment of various NHEJ factors, such as the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), DNA Ligase IV and X-ray cross complementing protein...
34 KB (4,130 words) - 03:55, 5 August 2024
there is a DNA test to determine if a given horse is a carrier of the allele. The only known form of horse SCID involves mutation in DNA-PKcs. Unlike SCID...
11 KB (1,429 words) - 01:31, 14 August 2024
Artemis (protein) (section Repair of DNA breaks)
combined immunodeficiency (SCIDA). DCLRE1C has been shown to interact with DNA-PKcs. GRCh38: Ensembl release 89: ENSG00000152457 – Ensembl, May 2017 GRCm38:...
14 KB (1,840 words) - 18:48, 24 January 2024