• Thumbnail for Enkephalin
    An enkephalin is a pentapeptide involved in regulating nociception (pain sensation) in the body. The enkephalins are termed endogenous ligands, as they...
    5 KB (554 words) - 00:23, 31 July 2024
  • Leu-enkephalin is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains...
    5 KB (364 words) - 02:50, 21 October 2021
  • Thumbnail for Met-enkephalin
    short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands...
    11 KB (1,002 words) - 14:38, 10 May 2024
  • Lasker Award for Basic Medical Research for the discovery of met-enkephalin and leu-enkephalin. This discovery demonstrated that opiate drugs exert their effects...
    7 KB (606 words) - 19:07, 26 March 2023
  • Thumbnail for Proenkephalin
    via proteolyic cleavage, produces the enkephalin peptides [Met]enkephalin, and to a lesser extent, [Leu]enkephalin. Upon cleavage, each proenkephalin peptide...
    6 KB (687 words) - 10:30, 3 December 2023
  • Thumbnail for Opioid receptor
    receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are ~40%...
    40 KB (4,427 words) - 12:37, 12 January 2024
  • Thumbnail for Endorphins
    Kosterlitz. They isolated "enkephalins" (from the Greek εγκέφαλος, cerebrum) from pig brain, identified as Met-enkephalin and Leu-enkephalin. This came after the...
    25 KB (2,604 words) - 14:36, 12 August 2024
  • Thumbnail for DADLE
    DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective δ-opioid receptor...
    3 KB (89 words) - 23:52, 28 October 2023
  • Thumbnail for RB-101
    breakdown of both kinds of enkephalin naturally found in the body, and so RB-101 causes a buildup of both Met-enkephalin and Leu-enkephalin. These peptides act...
    14 KB (1,510 words) - 07:43, 21 August 2024
  • Thumbnail for Opioid peptide
    gene for the enkephalins was isolated and its sequence described in 1982. The human gene for dynorphins (originally called the "Enkephalin B" gene because...
    19 KB (1,419 words) - 18:28, 15 March 2024