GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits. GABAA receptors including...
16 KB (1,639 words) - 05:16, 7 November 2023
Muscimol (category GABAA-rho receptor agonists)
potent and selective orthosteric agonist for the GABAA receptor. Muscimol, an agonist for the GABAA receptor, was able to significantly alleviate pain in...
39 KB (4,120 words) - 12:30, 22 July 2024
of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled...
35 KB (3,892 words) - 05:20, 16 May 2024
Allopregnanolone (category GABAA-rho receptor positive allosteric modulators)
is a neurosteroid and acts as a positive allosteric modulator of the GABAA receptor, the major biological target of the inhibitory neurotransmitter γ-aminobutyric...
50 KB (4,782 words) - 13:47, 19 July 2024
5α-Dihydroprogesterone (category GABAA-rho receptor negative allosteric modulators)
modulator of the GABAA-rho receptor. The steroid has been found to possess 82% of the affinity of progesterone for the progesterone receptor in rhesus monkey...
10 KB (909 words) - 23:12, 9 November 2023
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory...
53 KB (5,804 words) - 16:10, 26 June 2024
(Z)-4-Amino-2-butenoic acid (category GABAA-rho receptor agonists)
(Z)-4-Amino-2-butenoic acid (CACA, cis-4-aminocrotonic acid) is a GABA receptor partial agonist selective for the GABAA-ρ (previously known as GABAC) subtype. cis-4-Aminocrotonic...
3 KB (161 words) - 12:06, 18 September 2023
Gaboxadol (category GABAA-rho receptor antagonists)
α4β3δ GABAA receptors, low-potency agonist at α1β3γ2, and partial agonist at α4β3γ. Its affinity for this α4-containing subtype of the GABAA receptor is...
7 KB (550 words) - 21:38, 16 June 2024
Picrotoxin (category GABAA-rho receptor negative allosteric modulators)
1126/science.127.3297.521. PMID 13529017. Rho JM, Donevan SD, Rogawski MA (December 1996). "Direct activation of GABAA receptors by barbiturates in cultured rat...
17 KB (1,610 words) - 00:15, 19 May 2024
5β-Dihydroprogesterone (category GABAA-rho receptor negative allosteric modulators)
allopregnanolone) and also as a negative allosteric modulator of the GABAA-rho receptor. In accordance with the former action, it has been found to possess...
10 KB (908 words) - 11:09, 3 December 2023