dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene. Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation...
17 KB (2,094 words) - 06:10, 8 August 2024
enzymes isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2). The most common adverse reactions include fatigue, headache, increased...
11 KB (729 words) - 05:53, 22 August 2024
Glioma (section IDH1 and IDH2-mutated glioma)
and secondary high-grade gliomas. Wang et al. pointed out that IDH1 and IDH2 mutant cells produce an excess metabolic intermediate, 2-hydroxyglutarate...
61 KB (6,663 words) - 21:44, 7 August 2024
Mutations in the genes encoding for isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in 10–20% of patients with myelodysplastic syndrome, and confer a...
64 KB (7,099 words) - 23:51, 19 August 2024
acute myeloid leukemia. It is an inhibitor of isocitrate dehydrogenase 2 (IDH2). Common side effects of enasidenib include nausea, vomiting, diarrhea, increased...
9 KB (596 words) - 06:05, 8 August 2024
neoplasm. Cases in patients with Ollier disease has shown a link to IDH1, IDH2, and PTH1R gene mutations. Currently, there are no forms of treatment for...
29 KB (3,566 words) - 20:22, 3 December 2023
inhibiting isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2), respectively. Ivosidenib is specific to acute myeloid leukemia (AML) and...
26 KB (3,001 words) - 22:09, 5 July 2024
while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and...
33 KB (3,330 words) - 07:05, 3 April 2024
mutations include in the DNA demethylase TET2 and the metabolic enzymes IDH1 and IDH2, which lead to the generation of a novel oncometabolite, D-2-hydroxyglutarate...
75 KB (7,430 words) - 15:36, 9 August 2024
Pollock, Robin; O'Donnell, Paul; Grigoriadis, Anita (Jul 2011). "IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal...
11 KB (1,043 words) - 06:13, 1 August 2024