lectin receptor, (abbreviated to Mincle), is a member of the C-type lectin superfamily encoded by the gene CLEC4E. It is a pattern recognition receptor that...

signaling such as Dectin 1, and Dectin 2 – mincle signaling lead to MAP kinase and NFkB activation. Membrane receptor CLRs have been divided into 17 groups...

that cord factor is recognized by the Mincle receptor, which is found on macrophages. An activated Mincle receptor leads to a pathway that ultimately results...

and autophagy. Crystals can also directly activate inflammation via Mincle receptors, calcium and potassium signalling, calpains, cathepsin beta, proteases...

(CLEC9A) DCIR subfamily Dectin 2 (CLEC6A) BDCA2 (CD303) Mincle (CLEC4E) DCIR (CLEC4A) Scavenger receptors Class A - Trimers MSR1 (SCARA1) MARCO (SCARA2) SCARA3...

noninfectious inflammatory response by binding to a pattern recognition receptor (PRR). Inflammation is a key aspect of the innate immune response; it is...

dectin-2 cluster is composed of genes encoding dectin-2, DCIR, DCAR, BDCA-2, Mincle and Clecsf8, which are the members of the group II C-type lectin family...

factor inhibitor IκB, the vitamin D3 receptor VDR, Raf kinase, calpain, and the epidermal growth factor receptor. Upon activation, protein kinase C enzymes...

phagocytes are targeted. For example, mincle has been shown to be targeted by L. major. Interaction between mincle and a protein released by the parasite...

Miller, G. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. (2016) Nature. 532(7598):245-9. DOI: 10.1038/nature17403...