Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene. It is one of the targets of an oncomiR, MIRN21. This gene encodes...
8 KB (1,041 words) - 12:24, 8 April 2024
Q9BQ51 11844 PDCD2 HGNC:8762 Q16342 11845 PDCD2L HGNC:28194 Q9BRP1 11846 PDCD4 HGNC:8763 Q53EL6 11847 PDCD5 HGNC:8764 O14737 11848 PDCD6 HGNC:8765 O75340...
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Cell Death Protein 4 (PDCD4) is known to inhibit ATG5 expression via inhibition of protein translation. Two MA3 domains on PDCD4 bind to RNA-helicase EIF4A...
22 KB (2,808 words) - 09:48, 15 April 2024
eIF4A2, eIF4A3 DEAD-box RNA helicase. Binds mRNA, eIF4G, eIF4B, eIF4H, and PDCD4. Inhibited by the small molecules hippuristanol, rocaglamide A (RocA), and...
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phosphorylate programmed cell death 4 (PDCD4), which marks it for degradation by ubiquitin ligase Beta-TrCP (BTRC). PDCD4 is a tumor suppressor that binds to...
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Cmarik JL, Colburn NH (February 2001). "A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation"...
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hematopoietic cancers. It has been found to down-regulate the tumor suppressor PDCD4, thus aiding in the cancer's invasion, intravasation and metastasis. MicroRNA-155...
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PMID 29070863. Bai Y, Dong Z, Shang Q, Zhao H, Wang L, Guo C, et al. (2016). "Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density...
183 KB (12,460 words) - 13:46, 23 September 2024
the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21". Science Signaling. 4 (199): ra75. doi:10.1126/scisignal...
17 KB (1,949 words) - 09:42, 21 December 2023
Lankat-Buttgereit B, Müller S, Schmidt H, et al. (2008). "Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of...
8 KB (1,019 words) - 21:44, 3 September 2023