subunit alpha also known as Nav1.6 is a membrane protein encoded by the SCN8A gene. Nav1.6 is one sodium channel isoform and is the primary voltage-gated...
16 KB (2,001 words) - 07:51, 8 May 2024
through Nav1.9. The gene names are referred to as SCN1A through SCN5A, then SCN8A through SCN11A. The "tenth member", Nax, does not act in a voltage-gated...
34 KB (3,587 words) - 12:35, 24 June 2024
through Nav1.9. The gene names are referred to as SCN1A through SCN5A, then SCN8A through SCN11A. The "tenth member", Nax, does not act in a voltage-gated...
51 KB (5,600 words) - 16:44, 18 September 2024
unlike SCN1A mutations, patients often respond to sodium channel blockers. - SCN8A: This gene encodes the alpha-8 subunit (Nav1.6) and is primarily expressed...
33 KB (4,100 words) - 02:11, 22 October 2024
2018). "A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy". Epilepsia. 59 (4): 802–813. doi:10.1111/epi.14037. PMID 29574705...
92 KB (8,729 words) - 03:44, 26 October 2024
identified with LQT8. The sodium ion channel genes SCN1A, SCN1B, SCN2A, and SCN8A and the potassium channel KCNA1 have been implicated in both epilepsy and...
24 KB (2,710 words) - 10:10, 23 September 2024
SLC25A22, STXBP1, SPTAN1, KCNQ2, ARHGEF9, PCDH19, PNKP, SCN2A, PLCB1, SCN8A, ST3GAL3, TBC1D24, BRAT1 and likely others. Less often, the root of the...
15 KB (1,476 words) - 09:04, 31 July 2024
channels. The most closely related genes to paralytic in humans are SCN1A, SCN8A and SCN2A, all of which are genes that encode sodium channels. Mutations...
9 KB (981 words) - 07:54, 22 June 2024
PKD is genetically heterogeneous. Later reports have identified the genes SCN8A, CHRNA4, and SLC16A2 as further causes of PKD. The pathophysiology of PKD...
20 KB (2,205 words) - 18:47, 30 October 2024
2016-08-22. "PCDH19 and SCN8A Research Funded By The Cute Syndrome". The Cute Syndrome Foundation: Funding PCDH19 Epilepsy & SCN8A Epilepsy Research. Retrieved...
40 KB (4,237 words) - 16:28, 11 March 2024