Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are part of the seven-membered...
11 KB (1,215 words) - 11:33, 23 September 2023
STATs to dissociate from the receptor. At least STAT5 requires glycosylation at threonine 92 for strong STAT5 tyrosine phosphorylation. These activated STATs...
62 KB (6,845 words) - 18:30, 22 August 2024
models to downregulate downstream cytokine signaling by silencing STAT3 and STAT5 transcription activation (appelmann et al.). The interaction between JAK2...
29 KB (3,538 words) - 15:01, 5 December 2023
progenitor surface and activates a JAK2 signalling cascade. This initiates the STAT5, PIK3 and Ras MAPK pathways. This results in differentiation, survival and...
31 KB (3,430 words) - 05:24, 28 August 2024
with: Glucocorticoid receptor, Janus kinase 1, Janus kinase 2, and PTPN11. STAT5 GRCh38: Ensembl release 89: ENSG00000173757 – Ensembl, May 2017 GRCm38:...
5 KB (526 words) - 12:21, 14 January 2024
surface. GM-CSF signals via signal transducer and activator of transcription, STAT5. In macrophages, it has also been shown to signal via STAT3. The cytokine...
17 KB (1,672 words) - 11:59, 30 August 2023
avidity and sustained tumor immunity. Surprisingly no changes in activity of STAT5, CISH's purported target. Thus CISH represents a new class of T-cell intrinsic...
89 KB (10,338 words) - 14:21, 16 July 2024
stimulation by T-cell receptor of these cells. IL-33 in combination with some STAT5 activators, such as IL-2, IL-7 or TSLP, up-regulates expression of its own...
49 KB (6,005 words) - 16:30, 10 June 2024
TEC TNFRSF1A VAV1 YES1 Prolactin signals through JAK2 are dependent on STAT5, and on the RUSH transcription factors. Janus kinase inhibitor, medical...
28 KB (3,166 words) - 19:57, 8 August 2024
sites for a variety of intracellular pathway activators and Stats (such as Stat5). In addition to activating Ras/AKT and ERK/MAP kinase, phosphatidylinositol...
28 KB (3,409 words) - 18:05, 8 June 2024