Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. A pseudogene for this locus...

The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease...

especially common in people with a genetic deficiency of the enzyme thiopurine S-methyltransferase. Other serious risk factors include an increased risk of certain...

Examples of methyltransferase enzymes relevant to disease: thiopurine methyltransferase: defects in this gene causes toxic accumulation of thiopurine compounds...

deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Use in pregnancy may harm the baby. Mercaptopurine is in the thiopurine and antimetabolite...

reduction of the thiopurine, usually to one-third of the standard dose depending upon the patient's genetic status for thiopurine methyltransferase. Allopurinol...

when on the medication. People with a genetic deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Avoiding pregnancy when...

Q.; Pui, C. H.; Evans, W. E. (April 1, 1995). "Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts...

TPMT gene encodes for the thiopurine S-methyltransferase (TPMT) enzyme. It participates in the S-methylation of thiopurine drugs, which include 6-mercaptopurine...

One of his early studies investigated the correlation between thiopurine methyltransferase genotype and azathioprine toxicity in rheumatic disease patients...