• A trinucleotide repeat expansion, also known as a triplet repeat expansion, is the DNA mutation responsible for causing any type of disorder categorized...
    61 KB (7,973 words) - 11:50, 13 September 2024
  • In genetics, trinucleotide repeat disorders, a subset of microsatellite expansion diseases (also known as repeat expansion disorders), are a set of over...
    26 KB (2,709 words) - 18:38, 5 July 2024
  • Thumbnail for Slipped strand mispairing
    excision repair may involve strand slippage mispairing leading to trinucleotide repeat expansion when the repair is completed. Slipped strand mispairing has...
    10 KB (1,175 words) - 10:11, 22 March 2024
  • Thumbnail for Huntington's disease
    Huntington's disease (category Trinucleotide repeat disorders)
    huntingtin protein (Htt). Expansion of CAG repeats of cytosine-adenine-guanine (known as a trinucleotide repeat expansion) in the gene coding for the...
    137 KB (14,365 words) - 16:17, 28 September 2024
  • characterized by their propensity to change through mechanisms such as trinucleotide repeat expansion, slipped strand mispairing, or unequal crossing over during...
    20 KB (2,187 words) - 08:55, 5 October 2024
  • spinocerebellar ataxias, myotonic dystrophy and Friedreich's ataxia. Trinucleotide repeat expansions in the germline over successive generations can lead to increasingly...
    31 KB (3,652 words) - 06:24, 26 September 2024
  • the severity of symptoms is also noted. Anticipation is common in trinucleotide repeat disorders, such as Huntington's disease and myotonic dystrophy, where...
    5 KB (710 words) - 20:32, 5 December 2023
  • diseases are spinocerebellar ataxia and Huntington's disease. Trinucleotide repeat expansion occurring in a parental germline cell can lead to children that...
    4 KB (448 words) - 06:25, 16 June 2024
  • Thumbnail for Androgen insensitivity syndrome
    even the mutant AR protein itself can result in pathology. The trinucleotide repeat expansion of the polyglutamine tract of the AR gene that is associated...
    128 KB (12,638 words) - 22:10, 6 September 2024
  • Thumbnail for Fragile X-associated tremor/ataxia syndrome
    is defined as a trinucleotide repeat expansion of 55-200 CGG repeats in the Fragile X mental retardation-1 (FMR1) gene. 4-40 CGG repeats in this gene is...
    12 KB (1,303 words) - 12:29, 24 September 2022