Cytochrome P4502C8 (CYP2C8) is a member of the cytochrome P450 mixed-function oxidase system involved in the metabolism of xenobiotics in the body. Cytochrome...
14 KB (1,476 words) - 01:12, 10 July 2024
Montelukast (category CYP2C8 inhibitors)
enzyme CYP2C8, part of the cytochrome P450 system. Therefore, it is theoretically possible that the combination of montelukast with a CYP2C8 substrate...
27 KB (2,287 words) - 14:52, 7 September 2024
desloratadine by UGT2B10; then, 3-hydroxylation of desloratadine N-glucuronide by CYP2C8; and finally, a non-enzymatic deconjugation of 3-hydroxydesloratadine N-glucuronide...
14 KB (1,039 words) - 04:17, 1 June 2024
enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles. CYP2C8*1 is...
12 KB (1,042 words) - 19:40, 16 June 2024
Protein binding 10–36% Metabolism Primary: CYP1A2 Minor: CYP2E1, CYP3A4, CYP2C8, CYP2C9 Metabolites • Paraxanthine 84% • Theobromine 12% • Theophylline...
200 KB (20,047 words) - 22:51, 5 September 2024
in the metabolism of vortioxetine, but others including CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP3A4/5 are also involved. It is also metabolized...
56 KB (4,803 words) - 19:52, 31 August 2024
Quercetin (category CYP2C8 inhibitors)
Quercetin is a plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds, and grains; capers, red onions...
26 KB (2,467 words) - 14:07, 12 September 2024
metabolized by CYP3A4/5, though minor contributions by CYP1A2, CYP2D6, and CYP2C8 have been reported. CYP3A4 is the major enzyme involved in the N-dealkylation...
63 KB (5,650 words) - 05:22, 28 August 2024
low affinity. Buprenorphine is metabolized by the liver, via CYP3A4 (also CYP2C8 seems to be involved) isozymes of the cytochrome P450 enzyme system, into...
82 KB (7,486 words) - 02:58, 12 September 2024
CYP2C8 or CYP3A4 inhibitors may increase levels of apalutamide or its major active metabolite N-desmethylapalutamide, while mild to moderate CYP2C8 or...
36 KB (3,026 words) - 22:35, 16 August 2024