• Thumbnail for CYP2C8
    Cytochrome P4502C8 (CYP2C8) is a member of the cytochrome P450 mixed-function oxidase system involved in the metabolism of xenobiotics in the body. Cytochrome...
    14 KB (1,476 words) - 01:12, 10 July 2024
  • Thumbnail for Montelukast
    Montelukast (category CYP2C8 inhibitors)
    enzyme CYP2C8, part of the cytochrome P450 system. Therefore, it is theoretically possible that the combination of montelukast with a CYP2C8 substrate...
    27 KB (2,287 words) - 14:52, 7 September 2024
  • Thumbnail for Desloratadine
    desloratadine by UGT2B10; then, 3-hydroxylation of desloratadine N-glucuronide by CYP2C8; and finally, a non-enzymatic deconjugation of 3-hydroxydesloratadine N-glucuronide...
    14 KB (1,039 words) - 04:17, 1 June 2024
  • Thumbnail for Amodiaquine
    enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles. CYP2C8*1 is...
    12 KB (1,042 words) - 19:40, 16 June 2024
  • Thumbnail for Caffeine
    Protein binding 10–36% Metabolism Primary: CYP1A2 Minor: CYP2E1, CYP3A4, CYP2C8, CYP2C9 Metabolites • Paraxanthine 84% • Theobromine 12% • Theophylline...
    200 KB (20,047 words) - 22:51, 5 September 2024
  • Thumbnail for Vortioxetine
    in the metabolism of vortioxetine, but others including CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP3A4/5 are also involved. It is also metabolized...
    56 KB (4,803 words) - 19:52, 31 August 2024
  • Thumbnail for Quercetin
    Quercetin (category CYP2C8 inhibitors)
    Quercetin is a plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds, and grains; capers, red onions...
    26 KB (2,467 words) - 14:07, 12 September 2024
  • Thumbnail for Domperidone
    metabolized by CYP3A4/5, though minor contributions by CYP1A2, CYP2D6, and CYP2C8 have been reported. CYP3A4 is the major enzyme involved in the N-dealkylation...
    63 KB (5,650 words) - 05:22, 28 August 2024
  • Thumbnail for Buprenorphine
    low affinity. Buprenorphine is metabolized by the liver, via CYP3A4 (also CYP2C8 seems to be involved) isozymes of the cytochrome P450 enzyme system, into...
    82 KB (7,486 words) - 02:58, 12 September 2024
  • Thumbnail for Apalutamide
    CYP2C8 or CYP3A4 inhibitors may increase levels of apalutamide or its major active metabolite N-desmethylapalutamide, while mild to moderate CYP2C8 or...
    36 KB (3,026 words) - 22:35, 16 August 2024