Cav2.1, also called the P/Q voltage-dependent calcium channel, is a calcium channel found mainly in the brain. Specifically, it is found on the presynaptic...

TROX-1 is a drug which acts as a potent blocker of the Cav2 type calcium channels. It was developed as a potential analgesic after the discovery that the...

which encodes the P/Q-type calcium channel CaV2.1. Currently, 17 mutations in this channel are known (table 1), and these mutations are distributed throughout...

and Pharmacology of the Superfamilies (1 ed.). Boca Raton: CRC Press. doi:10.1201/9781003096276. ISBN 978-1-003-09627-6. S2CID 259784278. Wu, Jianping;...

main pore-forming α1 subunit (which is more specifically referred to as CaV2.1), an α2δ subunit and a β subunit. There can be γ subunits found in calcium...

repeat expansion beyond the normal range, i.e., more than 19 repeats, in the Cav2.1 calcium channel encoding gene CACNA1A. This gene has two splice forms, "Q-type"...

binding of the Ca2+-binding signaling protein calmodulin (CaM) to at least 1 site on the channel, as Ca2+-null CaM mutants abolish CGI in L-type channels...

voltage-gated calcium channels (VGCCs), including N-type (Cav2.2), R-type (Cav2.3), P/Q-type (Cav2.1), and L-type (Cav1.2) channels, with varying potencies...

calcium channel (Cav2.2) blocker and is highly selective for this channel over the related P/Q-type voltage-gated calcium channel (Cav2.1). Relative to ziconotide...

N-type calcium channels also called Cav2.2 channels are voltage gated calcium channels that are localized primarily on the nerve terminals and dendrites...