G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family...
14 KB (1,720 words) - 21:44, 25 May 2024
and cyclin E1. By inhibiting mir-424 in normal endothelial cells they could observe the same increased protein expression of MEK1 and cyclin E1 which...
17 KB (1,810 words) - 11:14, 14 December 2024
A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and...
10 KB (1,169 words) - 17:52, 15 August 2024
promote entry into S phase. Eukaryotic cells possess two types of cyclin, cyclin E1 and cyclin E2, with the protein sequences sharing 69.3% similarity in humans...
11 KB (1,404 words) - 07:30, 19 November 2024
transcription factor. Cyclin-dependent kinase 2 has been shown to interact with: BRCA1, CDK2AP1, CDKN1B CDKN3, CEBPA, Cyclin A1, Cyclin E1, Flap structure-specific...
35 KB (4,314 words) - 00:26, 6 July 2024
Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase of the cell cycle...
14 KB (1,638 words) - 18:17, 27 April 2024
cell cycle progression through Cyclin E1. More specifically, DDX3X was shown to directly bind to the 5ยด UTR of Cyclin E1, thereby facilitating the protein's...
17 KB (1,788 words) - 22:07, 1 December 2024
Palbociclib is less effective in patients whose breast cancer cells overexpress cyclin E1 or E2, and Brk (breast tumor-related kinase). Brk is an intracellular...
37 KB (3,558 words) - 20:55, 20 August 2024
Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk...
11 KB (1,334 words) - 23:16, 17 December 2024
switch-like transition between G1 and S-phase, and their components cyclin E1, cyclin E2, Skp2, and E2F1 are all transcribed early on at the G1/S transition...
17 KB (2,136 words) - 14:28, 17 December 2024