FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to...
28 KB (3,448 words) - 17:10, 16 April 2024
proliferation of effector T cells. Treg cells express the biomarkers CD4, FOXP3, and CD25 and are thought to be derived from the same lineage as naïve CD4+...
79 KB (9,493 words) - 15:51, 21 June 2024
IPEX syndrome (section FOXP3 gene)
IPEX is caused by mutations in the gene FOXP3, which encodes transcription factor forkhead box P3 (FOXP3). FOXP3 is widely considered to be the master regulator...
20 KB (2,002 words) - 15:32, 23 August 2023
X-linked syndrome (IPEX syndrome) is X-linked recessive due to mutation of the FOXP3 gene on the X chromosome. Most patients develop diabetes and diarrhea and...
10 KB (707 words) - 16:44, 19 August 2024
tumor. Forkhead box protein 3 (Foxp3) as a transcription factor is an essential molecular marker of Treg cells. Foxp3 polymorphism (rs3761548) might be...
35 KB (3,892 words) - 12:38, 3 August 2024
thymus. Two major classes of CD4+ Treg cells have been described—FOXP3+ Treg cells and FOXP3− Treg cells. Regulatory T cells can develop either during normal...
71 KB (9,026 words) - 12:33, 26 April 2024
factor beta (TGF-β). Th3 have been described both in mice and human as CD4+FOXP3− regulatory T cells. Th3 cells were first described in research focusing...
11 KB (1,235 words) - 01:34, 11 November 2023
nTreg cells develop from Foxp3- CD25+ CD4+ cells while iTreg cells develop from Foxp3+ CD25- CD4- cells (both become Foxp3+ CD25+CD4+). nTreg cells,...
50 KB (6,036 words) - 18:32, 12 August 2024
of developing asthma. Studies have shown a positive correlation between Foxp3 methylation and children's exposure to NO2, CO, and PM2.5. Furthermore,...
93 KB (10,537 words) - 09:55, 12 August 2024
acetylation in the promoter and conserved non-coding sequence regions of the FOXP3 locus, thus regulating the T cells, resulting in the reduction of the inflammatory...
49 KB (5,809 words) - 14:22, 17 August 2024