• Thumbnail for Ferroportin
    Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded...
    21 KB (2,439 words) - 01:30, 28 March 2024
  • Hemochromatosis type 4 is a hereditary iron overload disorder that affects ferroportin, an iron transport protein needed to export iron from cells into circulation...
    14 KB (1,716 words) - 14:58, 27 October 2023
  • Thumbnail for Human iron metabolism
    mammals, ferroportin. Hephaestin, a ferroxidase that can oxidize Fe2+ to Fe3+ and is found mainly in the small intestine, helps ferroportin transfer iron...
    46 KB (5,567 words) - 18:09, 20 August 2024
  • Thumbnail for Hepcidin
    low such as in hemochromatosis, iron overload occurs due to increased ferroportin mediated iron efflux from storage and increased gut iron absorption....
    22 KB (2,393 words) - 07:42, 23 February 2024
  • Thumbnail for Iron overload
    the iron regulatory proteins hemojuvelin, transferrin receptor-2 and ferroportin. Hereditary hemochromatosis is characterized by an accelerated rate of...
    46 KB (4,701 words) - 16:33, 16 September 2024
  • Thumbnail for African iron overload
    African people carry a unique ferroportin mutation that predisposes them iron overload, making it a kind of ferroportin disease. African-Americans, who...
    21 KB (2,165 words) - 00:46, 18 June 2024
  • and release from the liver. Hepcidin production and release shuts down ferroportin, a protein that controls export of iron from the gut and from iron storing...
    14 KB (1,640 words) - 21:27, 6 September 2024
  • Thumbnail for Manganese
    concentrations in excess of 5 μg Mn/m3 can lead to Mn-induced symptoms. Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated...
    86 KB (9,715 words) - 05:06, 26 September 2024
  • Thumbnail for Iron in biology
    mammals, ferroportin. Hephaestin, a ferroxidase that can oxidize Fe2+ to Fe3+ and is found mainly in the small intestine, helps ferroportin transfer iron...
    44 KB (5,376 words) - 09:18, 1 July 2024
  • Thumbnail for Acute-phase protein
    inhibiting microbe iron uptake Hepcidin Stimulates the internalization of ferroportin, preventing release of iron bound by ferritin within intestinal enterocytes...
    11 KB (1,096 words) - 14:00, 24 December 2023