Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids...
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Glucuronic acid (section Glucuronidation)
hydroxyl groups. This linkage process is known as glucuronidation (or glucuronide conjugation). Glucuronidation occurs mainly in the liver, although the enzymes...
17 KB (1,882 words) - 14:14, 7 August 2024
of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction. Alternative names: glucuronyltransferase UDP-glucuronyl transferase...
7 KB (679 words) - 22:07, 1 August 2024
Biotransformation (redirect from De-glucuronidation)
Biotransformation is the biochemical modification of one chemical compound or a mixture of chemical compounds. Biotransformations can be conducted with...
5 KB (556 words) - 03:32, 1 February 2024
body. The bilirubin-UGT enzyme performs a chemical reaction called glucuronidation. Glucuronic acid is transferred to unconjugated bilirubin, which is...
36 KB (3,719 words) - 12:42, 16 July 2024
3-hydroxydesloratadine in a three-step sequence in normal metabolizers. First, N-glucuronidation of desloratadine by UGT2B10; then, 3-hydroxylation of desloratadine...
14 KB (1,039 words) - 04:17, 1 June 2024
6-hydroxy- and 20-dihydro-triamcinolone; most of it probably undergoes glucuronidation, and a smaller part sulfation. Three quarters are excreted via the...
19 KB (1,498 words) - 19:56, 10 August 2024
bromazolam glucuronide, were detected as phase II metabolites. Bromazolam N-glucuronidation was found to be catalysed by UGT1A4 and UGT2B10. The formation of...
19 KB (2,022 words) - 08:38, 29 August 2024
irinotecan, is activated by hydrolysis to SN-38, and is then inactivated by glucuronidation by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1). The inhibition...
26 KB (2,315 words) - 04:55, 13 April 2024
possible therapeutic applications. Quercetin is rapidly metabolized (via glucuronidation) after the ingestion of quercetin foods or supplements. Five metabolites...
26 KB (2,467 words) - 22:10, 5 June 2024