HERC2 is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It is encoded by a gene of...

with eye color inheritance. Some of the eye-color genes include OCA2 and HERC2. The earlier belief that blue eye color is a simple recessive trait has...

deletion often occurs in individuals with either syndrome. A mutation in the HERC2 gene adjacent to OCA2, affecting OCA2's expression in the human iris, is...

skinned (having predominately derived alleles of SLC24A5, SLC45A2 and also HERC2/OCA2). Neolithic farmers entering Europe at around the same time were intermediate...

an inherited trait influenced by more than one gene, including OCA2 and HERC2. The interaction of multiple genes—and the variation in these genes ("alleles")...

frequency of the depigmentation alleles SLC45A2 and SLC24A5, and the OCA/Herc2, which affects eye pigmentation. These genes were much less common among...

LINC00340 (associated with spherical equivalent refractive error) and HERC2 (associated with eye color). Astigmatism may also occur following a cataract...

however, the main two genes associated with eye color variation are OCA2 and HERC2, and both are localized in chromosome 15. Before the discovery of DNA, scientists...

AD-associated GABA receptor gene cluster, GABRB3/GABRG3, and eye color genes, OCA2/HERC2, as well as between AD-associated GRM5 and pigmentation-associated TYR,...

1038/73389. PMID 10700162. S2CID 1418080. Harlalka, GV (2013). "Mutation of HERC2 causes developmental delay with Angelman-like features". Journal of Medical...