HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas, and stands for Human Melanoma Black. It...
4 KB (499 words) - 16:31, 12 October 2023
β-Hydroxy β-methylbutyric acid (HMB), otherwise known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans that...
106 KB (9,982 words) - 15:37, 7 January 2024
markers are relatively specific and include HMB-45, Melan-A, MITF, and tyrosinase. Specifically, HMB-45 staining intensity is highly specific and correlates...
33 KB (3,232 words) - 00:58, 29 June 2024
cuboidal cells within LAM lesions also react with a monoclonal antibody called HMB-45, developed against the premelanosomal protein gp100, an enzyme in the melanogenesis...
100 KB (11,094 words) - 13:43, 12 September 2024
diagnosis of melanoma is supported by the presence of the S-100 protein marker. HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic...
154 KB (16,086 words) - 03:37, 19 October 2024
growth factor. The absence of markers present in melanomas such as S100 and HMB-45 can help in differentiating angiosarcomas from melanomas. Angiosarcomas...
21 KB (2,157 words) - 18:51, 15 September 2024
protein (GCDFP-15) breast cancer, ovarian cancer, salivary gland cancer HMB-45 melanoma, PEComa (for example angiomyolipoma), clear cell carcinoma, adrenocortical...
22 KB (1,920 words) - 05:15, 6 March 2024
Pathology. 41 (11): 839–45. doi:10.1111/cup.12388. PMID 25263848. S2CID 9053425. Gleason BC, Nascimento AF (February 2007). "HMB-45 and Melan-A are useful...
41 KB (4,762 words) - 00:12, 13 June 2024
exhibits an immunohistochemical profile with S-100 protein-, vimentin-, and HMB-45-positive tumor cells. A melanocytoma most commonly occurs on or adjacent...
9 KB (1,045 words) - 07:36, 9 August 2024
without prominent nucleoli. PECs typically stain for melanocytic markers (HMB-45, Melan A (Mart 1), Mitf) and myogenic markers (actin, myosin, calponin)...
6 KB (532 words) - 02:46, 3 August 2024