kynurenine pathway include tryptophan, kynurenine, kynurenic acid, xanthurenic acid, quinolinic acid, and 3-hydroxykynurenine. The kynurenine pathway...
23 KB (2,404 words) - 17:15, 11 April 2024
l-Kynurenine is a metabolite of the amino acid l-tryptophan used in the production of niacin. Kynurenine is synthesized by the enzyme tryptophan dioxygenase...
22 KB (2,100 words) - 22:40, 4 June 2024
catabolic pathway. This enzyme belongs to the family of oxidoreductases, to be specific, those acting on paired donors, with O2 as the oxidant. Kynurenine 3-monooxygenase...
18 KB (1,970 words) - 10:11, 22 March 2024
precursor to niacin. Quinolinic acid is a downstream product of the kynurenine pathway, which metabolizes the amino acid tryptophan. It acts as an NMDA receptor...
31 KB (3,477 words) - 18:51, 20 November 2023
(L-Trp) to N-formyl-L-kynurenine, as the first and rate-limiting step of the kynurenine pathway. L-tryptophan + O2 ⇌ N-formyl-L-kynurenine Tryptophan 2,3-dioxygenase...
18 KB (2,094 words) - 14:33, 9 September 2023
Kynureninase (redirect from Kynurenine hydrolase)
Kynureninase or L-Kynurenine hydrolase (KYNU) (EC 3.7.1.3) is a PLP dependent enzyme that catalyses the cleavage of kynurenine (Kyn) into anthranilic acid...
8 KB (941 words) - 06:52, 3 June 2024
causes: Genetic defects in enzymes (e.g. kynureninase) involved in the kynurenine pathway of synthesis of niacin from tryptophan can lead to pellagra (niacin...
49 KB (3,959 words) - 17:56, 20 August 2024
sides by the two clusters of the genes involved in the well-studied kynurenine pathway and responsible for the production of 4-MHA from tryptophan, with...
20 KB (1,865 words) - 04:30, 3 January 2024
in the liver, are responsible for the synthesis of kynurenine from tryptophan. The kynurenine pathway of tryptophan catabolism is altered in several diseases...
46 KB (4,555 words) - 17:25, 29 July 2024
Picolinic acid is a catabolite of the amino acid tryptophan through the kynurenine pathway. Its function is unclear, but it has been implicated in a variety...
5 KB (446 words) - 00:48, 1 November 2023