NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that...
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Schregel, V; Jacobi, S; Penin, F; Tautz, N (2009). "Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3". Proc Natl Acad Sci U S A....
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Hepatitis C virus nonstructural protein 2 (redirect from NS2 (HCV))
segments. NS2 proteins are post-translationally processed by the HPV-encoded cysteine protease NS2-3, which is formed by residues 94-217 of NS2 itself as...
9 KB (1,152 words) - 00:49, 3 December 2023
membrane make up this structure. NS2-NS3 cleavage is mediated by the self-protease in NS2, which may effectively cleave into NS2 and NS3 in the early stages...
32 KB (3,927 words) - 10:08, 2 June 2024
The PA clan (Proteases of mixed nucleophile, superfamily A) is the largest group of proteases with common ancestry as identified by structural homology...
19 KB (1,689 words) - 07:38, 3 June 2024
lumen. NS2 protein is a 21–23 kilodalton (kDa) transmembrane protein with protease activity. NS3 is 67 kDa protein whose N-terminal has serine protease activity...
54 KB (6,593 words) - 11:14, 31 July 2024
making it an attractive therapeutic target. Unlike the viral enzymes (protease, reverse transcriptase and integrase) that are currently targeted by small-molecule...
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involvement of host proteins TSG101 and VPS-4". J. Virol. 77 (3): 1812–9. doi:10.1128/jvi.77.3.1812-1819.2003. PMC 140960. PMID 12525615. Silva LP, Vanzile...
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cleaved by cellular and viral proteases into three structural proteins (core, E1, and E2) and seven nonstructural proteins (p7, NS2, NS3, NS4A, NS4B, NS5A,...
50 KB (5,210 words) - 15:08, 16 May 2024
virus also has four auxiliary proteins — 2a, 4, 5a and I (or N2) (known as NS2, 15k, 12.6k and 7b in rat salivary adenophritis virus or as 2a, 5a, 5b and...
34 KB (4,193 words) - 11:02, 18 June 2024