• NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that...
    10 KB (1,355 words) - 21:53, 4 May 2023
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    Schregel, V; Jacobi, S; Penin, F; Tautz, N (2009). "Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3". Proc Natl Acad Sci U S A....
    2 KB (250 words) - 04:26, 16 July 2023
  • Thumbnail for Hepatitis C virus nonstructural protein 2
    segments. NS2 proteins are post-translationally processed by the HPV-encoded cysteine protease NS2-3, which is formed by residues 94-217 of NS2 itself as...
    9 KB (1,152 words) - 00:49, 3 December 2023
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    membrane make up this structure. NS2-NS3 cleavage is mediated by the self-protease in NS2, which may effectively cleave into NS2 and NS3 in the early stages...
    32 KB (3,927 words) - 10:08, 2 June 2024
  • Thumbnail for PA clan of proteases
    The PA clan (Proteases of mixed nucleophile, superfamily A) is the largest group of proteases with common ancestry as identified by structural homology...
    19 KB (1,689 words) - 07:38, 3 June 2024
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    lumen. NS2 protein is a 21–23 kilodalton (kDa) transmembrane protein with protease activity. NS3 is 67 kDa protein whose N-terminal has serine protease activity...
    54 KB (6,593 words) - 11:14, 31 July 2024
  • Thumbnail for P24 capsid protein
    making it an attractive therapeutic target. Unlike the viral enzymes (protease, reverse transcriptase and integrase) that are currently targeted by small-molecule...
    13 KB (1,461 words) - 20:04, 15 May 2024
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    involvement of host proteins TSG101 and VPS-4". J. Virol. 77 (3): 1812–9. doi:10.1128/jvi.77.3.1812-1819.2003. PMC 140960. PMID 12525615. Silva LP, Vanzile...
    7 KB (732 words) - 05:15, 15 April 2023
  • Thumbnail for Discovery and development of NS5A inhibitors
    cleaved by cellular and viral proteases into three structural proteins (core, E1, and E2) and seven nonstructural proteins (p7, NS2, NS3, NS4A, NS4B, NS5A,...
    50 KB (5,210 words) - 15:08, 16 May 2024
  • Thumbnail for Murine coronavirus
    virus also has four auxiliary proteins — 2a, 4, 5a and I (or N2) (known as NS2, 15k, 12.6k and 7b in rat salivary adenophritis virus or as 2a, 5a, 5b and...
    34 KB (4,193 words) - 11:02, 18 June 2024