Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed...
25 KB (3,085 words) - 18:04, 14 July 2024
inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including...
20 KB (2,065 words) - 16:33, 5 July 2024
Poly(ADP-ribose) polymerase family member 14 is a protein that, in humans, is encoded by the PARP14 gene. Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent...
1 KB (142 words) - 22:19, 3 March 2023
Pseudohypoxia (section Poly (ADP-ribose) polymerase-1)
oxidative damage done to cells in diabetes damages DNA and causes poly (ADP ribose) polymerases or PARPs to be activated, such as PARP1. Both processes reduce...
8 KB (875 words) - 21:33, 9 March 2024
first-in-class pharmaceutical drug targeting the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It is taken by mouth. The most common side effects include...
16 KB (1,208 words) - 07:07, 18 July 2024
Parthanatos (section Structure of PARP-1)
damage to the ROS is too great, PARP-1 will initiate cell death.[citation needed] Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that is found...
31 KB (3,633 words) - 00:02, 24 April 2024
ovarian cancer in adults. It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. It acts against cancers...
24 KB (2,132 words) - 11:10, 7 September 2024
name poly(ADP-ribose)polymerase. Originally, this group was thought to be a linear sequence of ADP-ribose units covalently bonded through a ribose glycosidic...
29 KB (3,535 words) - 13:23, 4 January 2024
C, Diefenbach J, Beneke S (May 2005). "The emerging role of poly(ADP-ribose) polymerase-1 in longevity". The International Journal of Biochemistry & Cell...
47 KB (5,529 words) - 14:28, 18 September 2024