as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has...

anophthalmia is mutated SOX2 gene. Sox2 anophthalmia syndrome is caused by a mutation in the Sox2 gene that does not allow it to produce the Sox2 protein that regulates...

pluripotent cells. Virally induced expression of four transcription factors Oct4, Sox2, c-Myc, and Klf4 (Yamanaka factors) is sufficient to create pluripotent (iPS)...

affected. In addition to HESX1, mutations in OTX2, SOX2 and PAX6 have been implicated in SOD. SOX2 mutations in SOD patients are associated with severe...

in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription...

promote differentiation, but are also controlled by levels of Sox2. A decrease in Sox2 accompanies increased levels of Oct-4 to promote a mesendodermal...

SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, containing at least 5 exons. The SOX2 gene, an important regulator of neurogenesis, lies...

SIX3 SIX6 SMOC1 SNX3 SOX2 SRD5A3 STRA6 TBC1D20 TBC1D32 TBX22 TCOF1 TENM3 TFAP2A TMEM98 TMEM67 TMX3 VAX1 VSX2 YAP1 ZEB2 ZIC2 SOX2 has been implicated in...

overexpressing in the primed pluripotent stem cell a reprogramming factor Klf4, or Sox2 and Klf4 (SK cocktail). Klf4 alone can reset mouse primed cells, but SK is...

treatment upon reflux of a large excess of thionyl chloride or thionyl bromide (SOX2) in the presence of a small amount of a nitrogen base, such as a tertiary...