Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate...
16 KB (1,902 words) - 00:29, 10 March 2024
Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy. This...
4 KB (380 words) - 10:51, 22 April 2024
Raltitrexed (category Thymidylate synthase inhibitors)
antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca. Used in treatment of colorectal...
5 KB (311 words) - 21:24, 14 July 2024
In enzymology, a thymidylate synthase (FAD) (EC 2.1.1.148) is an enzyme that catalyzes the chemical reaction 5,10-methylenetetrahydrofolate + dUMP + FADH2...
3 KB (244 words) - 16:03, 26 August 2023
Capecitabine is metabolised to 5-FU which in turn is a thymidylate synthase inhibitor, hence inhibiting the synthesis of thymidine monophosphate...
14 KB (1,105 words) - 06:03, 14 September 2024
(where uracil is used instead), inhibition of thymidine synthesis via thymidylate synthase selectively inhibits DNA synthesis over RNA synthesis. Due to their...
12 KB (1,314 words) - 05:55, 8 July 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
31 KB (2,908 words) - 06:38, 22 September 2024
Fluorouracil (category Thymidylate synthase inhibitors)
entirely clear, but it is believed to involve blocking the action of thymidylate synthase and thus stopping the production of DNA. Fluorouracil was patented...
31 KB (2,796 words) - 07:50, 10 August 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
9 KB (716 words) - 15:15, 27 October 2024
methyl group onto the uracil base of dUMP to generate dTMP. The thymidylate synthase reaction, dUMP + 5,10-methylenetetrahydrofolate ⇔ dTMP + dihydrofolate...
61 KB (6,770 words) - 15:11, 20 August 2024