Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular...

balance of Wee1 and Cdc25 activity with changes in cell size is coordinated by the mitotic entry control system. It has been shown in Wee1 mutants, cells...

employ such a mechanism, via Cdr2-mediated spatial regulation of Wee1 activity. Though Wee1 is a fairly conserved negative regulator of mitotic entry, no...

CyclinB-Cdc2 inhibitors, Wee1 and Myt1. Cdc25 activates the complex through the removal of phosphates from the active site while Wee1 inactivates the complex...

WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene. This gene encodes a nuclear protein, which is a...

phase, the CDK1 subunit of MPF is inactive due to an inhibitory enzyme, Wee1. Wee1 phosphorylates the Tyr-15 residue of CDK1, rendering MPF inactive. During...

based on early studies on TKIs aiming at VEGF receptors. Adavosertib is a Wee1 kinase inhibitor that is undergoing numerous clinical trials in the treatment...

drug candidate. It is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. It is being developed...

and reaches the G2/M transition, the kinase Plk1 phosphorylates Wee1, which targets Wee1 for degradation via the SCF ubiquitin ligase complex. An additional...

Pee Wee Crayton, singer WEE virus, the western equine encephalitis virus Wee1, a nuclear protein In the Wee Small Hours, album of Frank Sinatra In the...