Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins...
18 KB (2,026 words) - 20:25, 5 January 2024
(SINEs), selinexor works by binding to exportin 1 (also known as XPO1 or CRM1). XPO1 is a karyopherin which performs nuclear transport of several proteins...
30 KB (2,715 words) - 06:09, 16 July 2024
protein), alpha 1, DLG3, KIFAP3, MAPRE2, JUP, SIAH1, TFAP2A, TUBA4A and XPO1. MUTYH GRCm38: Ensembl release 89: ENSMUSG00000005871 – Ensembl, May 2017...
28 KB (3,225 words) - 01:48, 6 May 2024
nuclear export (SINEs or SINE compounds) are drugs that block exportin 1 (XPO1 or CRM1), a protein involved in transport from the cell nucleus to the cytoplasm...
4 KB (486 words) - 14:47, 17 September 2023
trial for multiple myeloma. In this trial, patients were treated with the XPO1 inhibitor selinexor. DarwinHealth scientists identified a Linear Discriminant...
10 KB (815 words) - 22:50, 20 May 2024
Protein 2 WDR47 WDR47 WD Repeat Domain 47 WDR62 WDR62 WD Repeat Domain 62 XPO1 XPO1/CRM1 Exportin 1 XRN1 XRN1 5'-3' Exoribonuclease 1 yes XRN2 XRN2 5'-3'...
183 KB (12,458 words) - 20:40, 1 July 2024
Q9NQW7 18392 XPNPEP2 HGNC:12823 O43895 18393 XPNPEP3 HGNC:28052 Q9NQH7 18394 XPO1 HGNC:12825 O14980 18395 XPO4 HGNC:17796 Q9C0E2 18396 XPO5 HGNC:17675 Q9HAV4...
242 KB (17 words) - 23:17, 27 April 2024
interact with: KPNB1, NEK9, NUTF2, RANBP1, RANGAP1, RCC1, TNPO1, TNPO2, XPO1, and XPO5. The expression of Ran is repressed by the microRNA miR-10a. GTPase...
17 KB (1,948 words) - 02:03, 17 June 2024
shown to interact with: MAPK1, Nuclear receptor coactivator 1, RFX5, RFXANK, XPO1, and ZXDC. MHC class II GRCh38: Ensembl release 89: ENSG00000179583 – Ensembl...
9 KB (1,097 words) - 05:37, 10 September 2023
exportin-1 (XPO1/CRM1) and Ran-GTP. Rev recruits this export machinery via a nuclear export sequence (NES) present in Rev. This Rev-RRE-Xpo1/RanGTP complex...
19 KB (2,218 words) - 14:35, 3 July 2024