1 susceptibility protein is a protein that in humans is encoded by the BRCA1 (/ˌbrækəˈwʌn/) gene. Orthologs are common in other vertebrate species, whereas...
121 KB (13,568 words) - 14:53, 22 October 2024
A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these...
72 KB (8,964 words) - 00:26, 24 July 2024
via homologous recombination. The well-known cancer susceptibility genes BRCA1 and BRCA2 are also examples of FA genes (FANCS and FANCD1 respectively)...
37 KB (4,138 words) - 03:05, 19 October 2024
caused by a combination of genetic, environmental and lifestyle factors. BRCA1 is an example of a genotype with reduced penetrance. By age 70, the mutation...
22 KB (2,454 words) - 08:30, 9 August 2024
HRDetect (section BRCA1/BRCA2)
is a whole-genome sequencing (WGS)-based classifier designed to predict BRCA1 and BRCA2 deficiency based on six mutational signatures. Additionally, the...
14 KB (1,809 words) - 07:59, 21 March 2024
are related to inherited genetic risk; women with mutations in the genes BRCA1 or BRCA2 have about a 50% chance of developing the disease. Some family...
198 KB (21,235 words) - 01:51, 17 October 2024
Cofactor of BRCA1, also known as COBRA1, is a human gene that encodes NELF-B. NELF-B is a subunit of negative elongation factor (NELF), which also includes...
11 KB (1,463 words) - 17:54, 20 November 2023
The genes BRCA1 and BRCA2 show loss of heterozygosity in samplings of tumors from patients who have germline mutations.[citation needed] BRCA1/2 are genes...
11 KB (1,419 words) - 19:38, 22 September 2024
If BRCA1 or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. BRCA1 and...
72 KB (7,870 words) - 01:08, 25 September 2024
are not known, a link with certain variants of BRCA1/2 has been described. Furthermore, women with BRCA1/2 mutation have a 5% risk of developing primary...
6 KB (503 words) - 19:09, 4 May 2024