Non-catalytic tyrosine-phosphorylated receptors (NTRs), also called immunoreceptors or Src-family kinase-dependent receptors, are a group of cell surface...
22 KB (2,445 words) - 07:22, 8 April 2024
triggering mechanism, the TCR belongs to the family of non-catalytic tyrosine-phosphorylated receptors (NTRs). In 1982, Nobel laureate James P. Allison first...
43 KB (5,372 words) - 15:31, 6 August 2024
Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins. Receptor tyrosine kinases have been...
28 KB (3,078 words) - 07:46, 3 June 2024
all receptors of the non-catalytic tyrosine-phosphorylated receptor family. The binding event allows phosphorylation of immunoreceptor tyrosine-based...
18 KB (2,173 words) - 16:05, 30 November 2023
A non-receptor tyrosine kinase (nRTK) is a cytosolic enzyme that is responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate...
21 KB (2,716 words) - 15:11, 26 August 2023
the cytoplasmic domains of many inhibitory receptors of the non-catalytic tyrosine-phosphorylated receptor family found on immune cells. These immune...
15 KB (1,799 words) - 13:02, 11 August 2024
the group of non-catalytic tyrosine-phosphorylated receptors which share a similar signalling pathway involving phosphorylation of tyrosine residues. The...
42 KB (4,735 words) - 03:31, 26 March 2024
insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase...
31 KB (3,785 words) - 16:28, 25 May 2024
the cytoplasmic tails of non-catalytic tyrosine-phosphorylated receptors such as the CD3 and ΞΆ-chains of the T cell receptor complex, the CD79-alpha and...
12 KB (1,273 words) - 09:18, 15 December 2023
"tyrosine phosphorylation inhibitor", originally coined in a 1988 publication, which was the first description of compounds inhibiting the catalytic activity...
10 KB (1,179 words) - 18:31, 8 August 2024