PIK3CA; HGNC ID, HGNC:8975), also called p110α protein, is a class I PI 3-kinase catalytic subunit. The human p110α protein is encoded by the PIK3CA gene...
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catalytic subunit alpha (p110α), inavolisib’s carbonyl group can accept a hydrogen bond from the Tyr836 (conserved) in p110α. The difluoromethyl group...
21 KB (2,184 words) - 23:28, 5 August 2024
There are also three variants of the p110 catalytic subunit designated p110α, β, or δ catalytic subunit. The first three regulatory subunits are all...
32 KB (3,463 words) - 17:34, 20 November 2023
Farías (P110), a patrol boat of the Mexican Navy Papyrus 110, a biblical manuscript p110α through p110δ, class I catalytic phosphoinositide 3-kinases P110, a state...
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molecule phosphoinositide 3-kinase inhibitor targeting the PI3K isoform p110α (PIK3CA). Roche announced in June 2018 that there would be no further development...
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p110δ regulates immune function. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells)...
23 KB (2,500 words) - 17:09, 28 June 2024
Dysplastic megalencephaly Klippel–Trénaunay syndrome PIK3CA gene codes for p110α protein which is a catalytic subunit of phosphoinositide 3-kinase, a major...
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of dual mTOR/PI3K inhibitors. These inhibitors target isoforms of PI3K (p110α, β and γ) along with ATP-binding sites of mTORC1 and mTORC2 by blocking...
57 KB (6,278 words) - 21:51, 24 August 2024
relation to breast tumors, somatic activating mutations in Akt and the p110α subunit of the PI3K have been detected in 3–5% and 20–25% of primary breast...
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p85 subunit of PI3K. ErbB3 binding causes the allosteric activation of p110α, the lipid kinase subunit of PI3K, a function not found in either EGFR or...
24 KB (2,816 words) - 23:40, 12 September 2024