trials, a surrogate endpoint (or surrogate marker) is a measure of effect of a specific treatment that may correlate with a real clinical endpoint but does...

powered. Surrogate endpoints are trial endpoints that have outcomes that substitute for a clinical endpoint, often because studying the clinical endpoint is...

functions Gradient-enhanced kriging (GEK) OptiY Space mapping Surrogate endpoint Surrogate data Fitness approximation Computer experiment Conceptual model...

artist Allan McCollum Surrogate model, used in engineering design Surrogate endpoint, a measure of effect in clinical trials Surrogate key, a unique database...

analysis of a surrogate endpoint at month twelve in a 54-month, randomized, double-blind placebo-controlled trial. The surrogate endpoint measured the...

before being brought to clinical trials. Some ideal characteristics of surrogate endpoint biomarkers include: Biomarker should be involved in process that causes...

measure that a drug is effective in treating the desired disease, and a surrogate endpoint is used to guide whether or not it is appropriate to proceed with...

surrogate or intermediate endpoints. RMAT goes beyond breakthrough therapy features by allowing for accelerated approval of drugs based on surrogate endpoints...

faster approval relies on use of surrogate endpoints. Drug approval typically requires clinical trials with endpoints that demonstrate a clinical benefit...

outcome measures. Outcome measures can be divided into clinical endpoints and surrogate endpoints where the former is directly related to what the goal of the...