dehydrogenase type 1 (3α-HSD1), is an enzyme that in humans is encoded by the AKR1C4 gene. It is known to be necessary for the synthesis of the endogenous neurosteroids...

gene encodes a particular isoform. The most studied isoforms are type 1 (AKR1C4), type 2 (AKR1C3) and type 3 (AKR1C2). Each of these isoforms shares higher...

5α-DHP is metabolized by the aldo-keto reductases (AKRs) AKR1C1, AKR1C2, and AKR1C4 with high catalytic efficiency. AKR1C1 preferentially forms 20α-hydroxy-5α-pregnane-3-one...

via 3α-reduction by a 3α-hydroxysteroid dehydrogenase isozyme (AKR1C2 and AKR1C4) or HSD17B6, that also has 3α-reduction activity. The pathway then proceeds...

includes the AKR1C and AKR1D subgroups, which respectively consist of AKR1C1–AKR1C4 and AKR1D1. Together with short-chain dehydrogenase/reductases (SDRs), these...

HGNC:384 Q04828 522 AKR1C2 HGNC:385 P52895 523 AKR1C3 HGNC:386 P42330 524 AKR1C4 HGNC:387 P17516 525 AKR1C8 HGNC:23469 Q5T2L2 526 AKR1D1 HGNC:388 P51857...

Turosteride • Vitamin B6 • Zinc 3α-HSDTooltip 3α-Hydroxysteroid dehydrogenase (AKR1C4) 5α-Dihydroprogesterone↔Allopregnanolone • DHDOC↔THDOC •...

Cao J, He QJ, Zhu H, Yang B (14 March 2017). "Aldo-Keto Reductase AKR1C1-AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy". Front...

PMID 11158055. human types 1 and 3 3α-HSD, 20α-HSD, and type 5 17β-HSD were named AKR1C4, AKR1C2, AKR1C1, and AKR1C3, respectively Human AKR1C3 genome location and...

dehydrogenase (3α-HSD), i.e. by the two aldo-keto reductase isozymes: AKR1C2 and AKR1C4, and by 17β-hydroxysteroid dehydrogenase 6 (HSD17B6) that also has the 3α-HSD...