MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. MDA5...

immune systems. Three RLR helicases have so far been described: RIG-I and MDA5 (recognizing 5'triphosphate-RNA and dsRNA, respectively), which activate...

characterized receptor within the RIG-I like receptor (RLR) family. Together with MDA5 (melanoma differentiation-associated 5) and LGP2 (laboratory of genetics...

results in cleavage of all RNA in the cell. This can lead to activation of MDA5, an RNA helicase involved in the production of interferons. RNase L is present...

the ribonuclease H2 enzyme complex), SAMHD1, ADAR1, and IFIH1 (coding for MDA5). This neurological disease occurs in all populations worldwide, although...

Melanoma Differentiation-Associated protein 5 (MDA5) and Laboratory of genetics physiology 2 (LGP2). RIG-I and MDA5 are both involved in activating MAVS and...

Misuse of Drugs Act (disambiguation) Missionary Diocese of All Saints (MDAS) MDA5, melanoma differentiation-associated protein 5 2,3-Methylenedioxyamphetamine...

located in the endosomal membrane and recognize double-stranded RNA (dsRNA), MDA5 and RIG-I receptors are located in the cytoplasm and recognize long dsRNA...

(RIG-I)-like receptors and melanoma differentiation-associated gene 5 (MDA5). RIG-I and MDA5 differ in the viral RNA that they recognize, but they share many...

(ExoN); N7 MTase adds 5′ cap, ExoN proofreads genome nsp15 Endoribonuclease (NendoU) nsp16 2′-O-Methyltransferase (2-O-MT); protects viral RNA from MDA5...