Prosaposin, also known as PSAP, is a protein which in humans is encoded by the PSAP gene. This highly conserved glycoprotein is a precursor for 4 cleavage...

All mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains four Saposin-B domains, yielding the active saposins after...

cases, it may be caused by a lack of active saposin A (a derivative of prosaposin). The buildup of unmetabolized lipids adversely affects the growth of...

angiogenesis. Moreover, stimulating TSP1 via over-expressing prosaposin or treating with a small prosaposin-derived peptide potently inhibits and even induces regression...

infantile Tay–Sachs Metachromatic leukodystrophy (MLD) Arylsulfatase A or prosaposin Sulfatide compounds in neural tissue Demyelination in CNS and PNS: Mental...

LAMP2, GNS/N-acetylglucosamine-6-sulfatase, TSPAN6/tetraspanin-6, PSAP/prosaposin, and TMEM192/transmembrane protein 192 may contribute to the execution...

Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: Prosaposin-like 1 (gene/pseudogene)". Retrieved 2013-04-11. v t e...

to interact with HSPA1A and Parkin (ligase). GPR37 is a receptor for prosaposin. It was previously thought to be a receptor for head activator, a neuropeptide...

protein Protein phosphatase with ef-hand domain 2 PSAPL1: encoding protein Prosaposin-like 1 (gene/pseudogene) QDPR: quinoid dihydropteridine reductase RBM47:...

lysosome. One recent study has shown that progranulin may actually mediate prosaposin trafficking to the lysosome via SORT1. However, the absence of SORT1 does...