encoded by the CUL4A gene. CUL4A belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates numerous...
36 KB (4,418 words) - 03:28, 3 December 2023
ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1), Cullin-4A (CUL4A), and regulator of cullins 1 (ROC1). This complex ubiquitinates a number...
12 KB (1,350 words) - 18:12, 22 April 2024
subunits. The larger subunit DDB1 primarily functions as a core component of CUL4A- and CUL4B-based E3 ubiquitin ligase complexes. Substrates that are ubiquitinnated...
31 KB (3,001 words) - 07:13, 14 August 2024
ligase, a complex consisting of DNA-binding protein 1 (DDB1), cullin 4a (CUL4A), regulator of cullins 1 (ROC1), and cereblon (CRBN). Cereblon is the substrate...
29 KB (2,483 words) - 05:43, 9 August 2024
that in humans is encoded by the DCAF15 gene. DCAF15 forms a complex with CUL4A or CUL4B that has E3 ubiquitin ligase activity and is responsible for the...
965 bytes (144 words) - 06:15, 28 March 2022
ECS complex (Elongin C - CUL2 - SOCS-box) CUL3, part of CUL3-BTB complex CUL4A CUL4B CUL5 CUL7 CUL9, also known as PARC There is also a more distant member...
7 KB (718 words) - 21:57, 20 September 2023
researchers have found that DDB1 primarily functions as a core component of the CUL4A- and CUL4B-based E3 ubiquitin ligase complexes. DDB1 serves as a bridge...
12 KB (1,415 words) - 16:33, 23 December 2023
DDB1. This complex further complexes with the ubiquitin ligase protein CUL4A and with PARP1. This larger complex rapidly associates with UV-induced damage...
129 KB (15,900 words) - 06:12, 13 August 2024
with UV light, DDB2, in a complex with DDB1, the ubiquitin ligase protein CUL4A and the RING finger protein ROC1, associates with sites of damage within...
79 KB (9,956 words) - 00:33, 25 August 2024
lost appendages. P21 has been shown to interact with: Nrf2 BCCIP, CIZ1, CUL4A, CCNE1, CDK, DDB1, DTL, GADD45A, GADD45G, HDAC, PCNA, PIM1, TK1, and TSG101...
34 KB (3,978 words) - 08:00, 23 February 2024