lymphocytes. The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates...
14 KB (1,447 words) - 09:31, 22 December 2023
their C terminus. Although the IκB family consists of IκBα, IκBβ, IκBε, and Bcl-3, the best-studied and major IκB protein is IκBα. Due to the presence of ankyrin...
89 KB (9,773 words) - 14:28, 22 August 2024
lose the pro-apoptotic function. Akt1 can also activate NF-κB via regulating IκB kinase (IKK), thus result in transcription of pro-survival genes. The...
35 KB (3,831 words) - 18:08, 20 August 2024
CHUK (redirect from Conserved helix-loop-helix ubiquitous kinase)
by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has...
23 KB (2,765 words) - 20:13, 7 July 2024
embryonic lethality in mice. Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a...
20 KB (2,296 words) - 02:36, 29 November 2023
IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; NFKBIA) is one member of a family of cellular proteins that function...
13 KB (1,526 words) - 18:27, 5 February 2024
5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular...
65 KB (7,149 words) - 04:45, 26 August 2024
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA...
27 KB (2,665 words) - 17:03, 6 April 2024
of mitogen-activated protein kinases (MAPKs) and the IκB kinase (IKK) complex, which initiates a nuclear factor-κB (NF-κB) and AP-1-dependent transcriptional...
30 KB (3,637 words) - 08:49, 24 August 2024
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses...
46 KB (5,492 words) - 14:52, 20 August 2024