hMSH6 (human MSH6). The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair. Defects in hMSH6 are...
23 KB (2,942 words) - 20:15, 5 April 2024
repair pathway: People with MSH6 mutations are more likely to be Amsterdam criteria II-negative. The presentation with MSH6 is slightly different from...
47 KB (4,902 words) - 21:19, 19 February 2024
DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with MSH3...
35 KB (4,241 words) - 13:05, 19 July 2024
sebaceous tumors. The genes affected are MLH1, MSH2, and more recently, MSH6, and are involved in DNA mismatch repair. Muir–Torre syndrome is characterized...
13 KB (1,492 words) - 18:16, 3 December 2023
in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–08. doi:10.1093/carcin/bgl079. PMC 2612936...
185 KB (19,980 words) - 18:58, 16 July 2024
cytoreduction of tumors with temozolomide and then selection or induction of mutant MSH6, MSH2, MLH1, or PMS2 proteins and cells which are MMRd and temozolomide resistant...
33 KB (2,959 words) - 02:09, 16 July 2024
genetic mutations in DNA mismatch repair (MMR) genes, notably MLH1, MSH2, MSH6 and PMS2. In addition to colorectal cancer many other cancers are increased...
51 KB (5,582 words) - 14:19, 15 July 2024
in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936...
51 KB (5,873 words) - 12:19, 15 July 2024
particularly early-onset prostate cancer – including BRCA1, ATM, NBS1, MSH2, MSH6, PMS2, CHEK2, RAD51D, and PALB2. Additionally, variants in the genome near...
76 KB (8,857 words) - 11:18, 18 June 2024
mismatch site. In eukaryotes, MutS homologs form two major heterodimers: Msh2/Msh6 (MutSα) and Msh2/Msh3 (MutSβ). The MutSα pathway is involved primarily in...
35 KB (4,179 words) - 12:12, 19 July 2024