Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is co-secreted with insulin from the pancreatic β-cells in the ratio of...
33 KB (4,044 words) - 20:39, 24 August 2024
The amylin receptors (AMYRs) are heterodimers of the calcitonin receptor that are bound to by amylin with high affinity and consist of AMY1, AMY2, and...
4 KB (468 words) - 20:43, 23 April 2024
Dual amylin and calcitonin receptor agonists (DACRAs) are a class of drugs that act as agonists at the amylin receptor and calcitonin receptor that are...
3 KB (351 words) - 20:55, 25 April 2024
Amylin Pharmaceuticals, Inc. is a biopharmaceutical founded in 1987 that was based in San Diego, California. The company was engaged in the discovery,...
14 KB (1,253 words) - 22:25, 14 August 2024
Cagrilintide (category Amylin receptor agonists)
Cagrilintide is a long-acting analogue of amylin. It is being tested to treat obesity and type 2 diabetes by itself and in combination with semaglutide...
10 KB (415 words) - 13:40, 6 August 2024
of Langerhans responsible for the production and release of insulin and amylin. Constituting ~50–70% of cells in human islets, beta cells play a vital...
32 KB (3,743 words) - 19:49, 22 May 2024
Petrelintide (category Amylin receptor agonists)
Petrelintide (development name ZP8396) is an amylin analogue dosed once weekly, developed by Zealand Pharma for the treatment of type 2 diabetes and obesity...
5 KB (262 words) - 13:57, 21 August 2024
Cagrilintide/semaglutide (category Amylin receptor agonists)
Cagrilintide/semaglutide, marketed as CagriSema, is a combination of cagrilintide, a dual amylin and calcitonin receptor agonist, and semaglutide, a GLP-1 agonist. It is...
6 KB (422 words) - 13:41, 6 August 2024
Pramlintide (category Amylin receptor agonists)
(trade name Symlin) is an injectable amylin analogue drug for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals (now a wholly owned subsidiary...
11 KB (720 words) - 02:15, 27 April 2024
diabetes. CCL2 induces amylin expression through ERK1/ERK2/JNK-AP1 and NF-κB related signaling pathways independent of CCR2. Amylin upregulation by CCL2...
20 KB (2,419 words) - 23:03, 5 September 2024