Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene. Histones play a critical role in transcriptional...

deacetylase 4 (HDAC4) gene, have been linked to anorexia. While the ESRRA mutation decreases its transcriptional activity, the HDAC4 mutation increases...

mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......

nucleus and the cytoplasm, and is also membrane-associated. Class II HDACs (HDAC4, 5, 6, 7 9, and 10) are able to shuttle in and out of the nucleus, depending...

(HDAC4), which allows HDAC4 to be imported from the cytosol, where the oxidized form resides, into the nucleus. Once in the nucleus, reduced HDAC4 downregulates...

mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......

mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......

Inhibited enzyme IC50 (nM) Entry note HDAC1 16,000 HDAC2 12,000 HDAC3 9,000 HDAC4 2,000,000 Lower bound HDAC5 2,000,000 Lower bound HDAC6 2,000,000 Lower...

is thought to contribute to contractility. The Class IIA HDACs includes HDAC4, HDAC5, HDAC7 and HDAC9. HDACs 4 and 5 have been found to most closely resemble...

re-entry of post-mitotic (mature) neurons Synaptic/vesicular dysregulation HDAC4 dysregulation Histone hypermethylation and altered epigenetics Altered protein...