shock factor 1 (HSF 1) is a protein that in humans is encoded by the HSF1 gene. HSF1 is highly conserved in eukaryotes and is the primary mediator of transcriptional...
20 KB (2,453 words) - 17:40, 22 August 2024
shock factor 1 (HSF1). There are four different transcription factors found in vertebrates (HSF 1–4) where the main regulator of HSPs is HSF1, while σ32 is...
21 KB (2,437 words) - 05:40, 27 May 2024
complex. Thus, the MS2 protein is engineered to include p65 and HSF1 proteins. The MS2-p65-HSF1 fusion protein interacts with the dCas9-VP64 to recruit more...
21 KB (2,672 words) - 09:24, 16 August 2024
expression. Recently it was discovered that HSF1 is a powerful multifaceted modifier of carcinogenesis. HSF1 knockout mice show significantly decreased...
49 KB (5,533 words) - 10:41, 19 July 2024
in humans is encoded by the HSF2 gene. HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and...
8 KB (973 words) - 08:34, 10 June 2024
"Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1-Hsp90 pathway". PLOS Biology. 17 (3): e2006966. doi:10.1371/journal.pbio...
89 KB (9,969 words) - 15:13, 14 June 2024
Research studying the role of the master regulator of the heat shock response, HSF1, in the development of cancer. In 2013, he started his research laboratory...
16 KB (1,492 words) - 18:10, 3 December 2023
ENSG00000128709 Homeodomain Known motif – High-throughput in vitro [410] TTTTATKRC HSF1 ENSG00000185122 HSF Known motif – High-throughput in vitro [411] VGAABVTTCBVGAW...
374 KB (81 words) - 02:10, 23 September 2023
proteins bind to the misfolded proteins and dissociate from HSF-1. This allows HSF1 to form trimers and translocate to the cell nucleus and activate transcription...
7 KB (743 words) - 14:33, 3 December 2023
dissociation of inactive HSF1 from complexes with heat shock proteins Hsp40/Hsp70 and Hsp90. With help from the ncRNA hsr1, HSF1 then trimerizes, becoming...
63 KB (7,609 words) - 04:41, 21 June 2024