Irinotecan, sold under the brand name Camptosar among others, is an anti-cancer medication used to treat colon cancer and small cell lung cancer. For colon...

active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro...

which incorporates into the DNA molecule and stops synthesis; and IRI – irinotecan (Camptosar), a topoisomerase inhibitor, which prevents DNA from uncoiling...

Europe during the Cold War. Atropine has been observed to prevent or treat irinotecan induced acute diarrhea. Adverse reactions to atropine include ventricular...

effectiveness to prevent diarrhea in cancer patients who have received irinotecan. It can interfere with the absorption of some medications, and lead to...

]] [[ ]] [[ ]] [[ ]] |alt=Irinotecan Pathway edit]] The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229". Glucuronosyltransferase...

Romidepsin Vorinostat Zabadinostat Belotecan Camptothecin Exatecan Gimatecan Irinotecan Topotecan Etoposide Teniposide Tafluposide Bortezomib Erlotinib Gefitinib...

inhibitors. One of the first inhibitors shown to target TOP1 is irinotecan. Irinotecan is an analogue of the cytotoxic natural alkaloid camptothecin, obtained...

colorectal cancer who received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type and medically...

antineoplastic agent, which inhibits DNA repair and/or DNA synthesis; IRI – irinotecan (Camptosar), a topoisomerase inhibitor, prevents DNA from uncoiling and...