Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate...
21 KB (2,334 words) - 09:36, 10 June 2024
Telomere (redirect from Shelterin complex)
by several proteins, collectively referred to as the shelterin complex. In humans, the shelterin complex consists of six proteins identified as TRF1,...
43 KB (4,840 words) - 05:22, 12 August 2024
forming a complex known as shelterin. There are six subunits forming the telomere-binding protein complex known as shelterin: TERF1, TERF2, POT1, TIN2...
13 KB (1,658 words) - 08:34, 4 December 2022
length at a rate of approximately 25 nucleotides per year. The telomere-shelterin complexes that cap all eukaryotic chromosomes ensure that healthy cells...
22 KB (2,640 words) - 02:45, 1 December 2023
named shelterin, named for its function of protecting chromosome ends. The six shelterin subunits are: TRF1, TRF2, TIN2, Rap1, TPP1, and POT1. Shelterin subunits...
15 KB (1,654 words) - 21:36, 23 February 2024
important role in regulating total TERRA expression. Additionally, the Shelterin component TRF1 has been shown to support TERRA transcription. As part...
35 KB (4,668 words) - 11:25, 11 February 2024
the functions that shelterin performs in vertebrates. At least four factors contribute to telomere maintenance: telomerase, shelterin, TERRA and the CST...
5 KB (514 words) - 00:25, 4 December 2023
6-nucleotide sequences that cap the ends of chromosomes. TERRA functions with shelterin to inhibit telomere lengthening by enzyme telomerase. However, other studies...
3 KB (312 words) - 22:54, 9 April 2024
sequenced. The shelterin protein TPP1 is both necessary and sufficient to recruit the telomerase enzyme to telomeres, and is the only shelterin protein in...
49 KB (5,644 words) - 06:05, 27 April 2024
and is encoded in humans by the TERF2 gene. It is a component of the shelterin nucleoprotein complex and a second negative regulator of telomere length...
27 KB (3,340 words) - 22:06, 22 December 2023